品牌：源叶(MedMol)

产品编号：S86117 一键复制产品信息

CAS号：656247-18-6

分子式：C₃₁H₃₃N₅O₄.C₂H₆O₃S

分子量：649.75706

别名：尼达尼布乙磺酸盐;(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐;乙磺酸尼达尼布;尼达尼布单乙基磺酸盐;(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethy

货号	规格	价格	上海	北京	珠海	重庆	武汉
S86117-5mg买3赠1	99.90%	￥190.00 S86117-5mg ￥190.00 现货（买3赠1）	3906 >10	-	-	-	-
S86117-10mg买3赠1	99.90%	￥290.00 S86117-10mg ￥290.00 现货（买3赠1）	1959 >10	-	-	-	-
S86117-50mg买3赠1	99.90%	￥710.00 S86117-50mg ￥710.00 现货（买3赠1）	395 >10	-	-	-	-
S86117-100mg买3赠1	99.90%	￥1050.00 S86117-100mg ￥1050.00 现货（买3赠1）	206 >10	-	-	-	-
S86117-250mg买3赠1	99.90%	￥1900.00 S86117-250mg ￥1900.00 现货（买3赠1）	79 >10	-	-	-	-

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产品描述：

Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

靶点：

VEGFR1:34 nM (IC50);VEGFR2:13 nM (IC50);VEGFR3:13 nM (IC50);FGFR1:69 nM (IC50);FGFR2:37 nM (IC50);FGFR3:108 nM (IC50);PDGFRα:59 nM (IC50);PDGFRβ:65 nM (IC50);VEGFR;FGFR;PDGFR

体内研究：

Nintedanib (BIBF 1120) (25-100 mg/kg daily p.o.) is highly active in all tumor models, including human tumor xenografts growing in nude mice and a syngeneic rat tumor model. This is evident in the magnetic resonance imaging of tumor perfusion after 3 days, reducing vessel density and vessel integrity after 5 days, and profound growth inhibition[1]. Nintedanib (BIBF 1120) is orally available and displays encouraging efficacy in in vivo tumor models while being well tolerated

参考文献：

1. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. 2. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130. 3. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480.

溶解性：

Soluble in DMSO、Ethanol、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.539 ml	7.695 ml	15.39 ml
5 mM	0.308 ml	1.539 ml	3.078 ml
10 mM	0.154 ml	0.77 ml	1.539 ml
50 mM	0.031 ml	0.154 ml	0.308 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=15.153] Dongjun Li et al."Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis."Small.2023 Apr;:2300545

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Nintedanib Ethanesulfonate Salt