货号	规格	价格	上海	北京	珠海	重庆	武汉
S86172-10mg促销	98%	￥278.00 ￥250.00 S86172-10mg ￥250.00 现货	10 10	-	-	-	-
S86172-50mg促销	98%	￥686.00 ￥618.00 S86172-50mg ￥618.00 现货	10 10	-	-	-	-
S86172-100mg促销	98%	￥1090.00 ￥989.00 S86172-100mg ￥989.00 现货	7 0 7	-	-	-	-
S86172-500mg促销	98%	￥4630.00 ￥4170.00 S86172-500mg ￥4170.00 现货	2 2	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 dihydrochloride stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 dihydrochloride also prevents the d-Fenfluramine-induced head-twitch response in mice

靶点：

Dopamine Transporter;DopamineReceptor

体内研究：

GBR 12935 dihydrochloride (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections Animal Model: Adult male DBA/2J and C57BL/6J mice (22-30 g) Dosage: 1.0, 3.2, 10, 32 mg/kg Administration: Repeat injection; for 7 days Result: Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice.No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 dihydrochloride in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline.

参考文献：

1. Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. 2. Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44. 3. Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.051 ml	10.256 ml	20.513 ml
5 mM	0.41 ml	2.051 ml	4.103 ml
10 mM	0.205 ml	1.026 ml	2.051 ml
50 mM	0.041 ml	0.205 ml	0.41 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

GBR 12935 二盐酸盐

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)