货号	规格	价格	上海	北京	武汉	南京	购买数量
S86193-100mg	98%，(5E,9E,13E)- and(5Z,9E,13E)- isomers	￥160.00 S86193-100mg ￥160.00 现货	3 3	-	-	-
S86193-500mg	98%，(5E,9E,13E)- and(5Z,9E,13E)- isomers	￥400.00 S86193-500mg ￥400.00 现货	7 7	-	-	-

产品介绍

Teprenone is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

产品描述：

Teprenone is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

靶点：

HSP

体内研究：

Teprenone (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, and the accumulation is enhanced by stress addition in the mucosa of Teprenone-pretreated rats compared with that of vehicle-pretreated rats. Teprenone (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- and 4-hour stress loading in rats. Teprenone (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Teprenone significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, and increases HSP72 in a rat model of glaucoma. Teprenone (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice

参考文献：

1. Hirakawa T, et al. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology. 1996 Aug;111(2):345-57. 2. Caprioli J, et al. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Trans Am Ophthalmol Soc. 2003;101:39-50; discussion 50-1. 3. Han NK, et al. Geranylgeranylacetone Ameliorates Intestinal Radiation Toxicity by Preventing Endothelial Cell Dysfunction. Int J Mol Sci. 2017 Oct 7;18(10).

溶解性：

Soluble in DMSO、Ethanol

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.025 ml	15.126 ml	30.252 ml
5 mM	0.605 ml	3.025 ml	6.05 ml
10 mM	0.303 ml	1.513 ml	3.025 ml
50 mM	0.061 ml	0.303 ml	0.605 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Teprenone