货号	规格	价格	上海	北京	珠海	重庆	武汉
S86204-5mg	≥99%	￥760.00 S86204-5mg ￥760.00 3-5天	0 货期：3-5天	-	-	-	-
S86204-10mg	≥99%	￥1340.00 S86204-10mg ￥1340.00 3-5天	0 货期：3-5天	-	-	-	-
S86204-25mg	≥99%	￥2840.00 S86204-25mg ￥2840.00 3-5天	0 货期：3-5天	-	-	-	-
S86204-50mg	≥99%	￥5090.00 S86204-50mg ￥5090.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM

靶点：

IC50: 0.67 μM (AFABP/aP2)

体外研究：

HTS01037 functions as a high affinity ligand of AFABP/aP2 with an apparent Ki of 0.67 μM. HTS01037 is somewhat selective for AFABP/aP2, but at higher concentrations is a pan-specific FABP inhibitor. HTS01037 inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. HTS01037 acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophage or CV-1 cells. Treatment of microglial cells with HTS01037 increases expression of Ucp2 and arginase in the presence or absence of palmitic acid. Moreover, cells exposed to HTS01037 exhibits attenuated expression of inducible nitric oxide synthase (iNOS) compared to palmitic acid alone indicating reduced NFκB signaling. Treatment of macrophages with HTS01037results in a marked decrease in both basal and fatty acid-stimulated LTC4 secretion but no change in 5-HETE production or 5-lipoxygenase expression

参考文献：

1. Hertzel AV, et al. Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J Med Chem. 2009 Oct 8;52(19):6024-31. 2. Duffy CM, et al. Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation. Mol Cell Neurosci. 2017 Apr;80:52-57. 3. Long EK, et al. Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. Biochim Biophys Acta. 2013 Jul;1831(7):1199-207.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.964 ml	14.82 ml	29.641 ml
5 mM	0.593 ml	2.964 ml	5.928 ml
10 mM	0.296 ml	1.482 ml	2.964 ml
50 mM	0.059 ml	0.296 ml	0.593 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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