| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86330-5mg买3赠1 |
99.10% | ￥352.00 |
3 | - | - | - | - |
|
S86330-10mg买3赠1 |
99.10% | ￥520.00 |
6 | - | - | - | - |
|
S86330-25mg买3赠1 |
99.10% | ￥1020.00 |
6 | - | - | - | - |
|
S86330-100mg买3赠1 |
≥98% | ￥3260.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and Erβ | ||||||||||||||||||||
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| 靶点： | ERRα:0.37 μM (IC50);EstrogenReceptor/ERR;Estrogen/progestogenReceptor;Autophagy | ||||||||||||||||||||
| 体内研究： | XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) significantly inhibits tumor growth and angiogenesis, and induces apoptosis without a reduction in body weight, in xenograft models | ||||||||||||||||||||
| 参考文献： | 1. Wu F, et al. Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells. Chem Biol Interact. 2009 Oct 7;181(2):236-42. 2. Kokabu T, et al. Antitumor effect of XCT790, an ERRα inverse agonist, on ERα-negative endometrial cancer cells. Cell Oncol (Dordr). 2019 Apr;42(2):223-235. 3. Busch BB, et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem. 2004 Nov 4;47(23):5593-6. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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