货号	规格	价格	上海	北京	珠海	重庆	武汉
S86340-2mg买3赠1	98.10%	￥650.00 S86340-2mg ￥650.00 现货（买3赠1）	8 8	-	-	-	-
S86340-5mg买3赠1	98.10%	￥900.00 S86340-5mg ￥900.00 现货（买3赠1）	6 6	-	-	-	-
S86340-10mg买3赠1	98.10%	￥1440.00 S86340-10mg ￥1440.00 现货（买3赠1）	7 7	-	-	-	-
S86340-25mg买3赠1	98.10%	￥2800.00 S86340-25mg ￥2800.00 现货（买3赠1）	7 7	-	-	-	-
S86340-50mg买3赠1	98.10%	￥4050.00 S86340-50mg ￥4050.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.

靶点：

Ki: 4 nM (Escherichia coli LpxC);Antibacterial

体内研究：

CHIR-090 is a potent antibiotic against E. coli and inhibits E. coli LpxC activity in vitro in the low nM range. E. coli W3110 colonies resistant to 1 μg/mL CHIR-090 are not observed without prior chemical mutagenesis. A strain of E. coli W3110 is able to grow on LB agar plates containing 1 to 10 μg/mL CHIR-090, which is 4 to 40 times above the MIC of 0.25 μg/mL under our conditions for wild-type E. coli W3110. The doubling time of W3110RL is 40 min in the presence of 1 μg/mL CHIR-090, which is exactly the same rate as wild-type in the absence of inhibitor. Wild-type cells stopped growing after about 2 h in the presence of 1 μg/mL CHIR-090

参考文献：

1. Barb AW, et al. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 2007 Mar 27;46(12):3793-802. 2. Barb AW, et al. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8. 3. Tan JH, et al. In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02223-16.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.286 ml	11.429 ml	22.858 ml
5 mM	0.457 ml	2.286 ml	4.572 ml
10 mM	0.229 ml	1.143 ml	2.286 ml
50 mM	0.046 ml	0.229 ml	0.457 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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