| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86342-2mg买3赠1 |
99.90% | ￥244.00 |
8 | - | - | - | - |
|
S86342-5mg买3赠1 |
99.90% | ￥326.00 |
7 | - | - | - | - |
|
S86342-10mg买3赠1 |
99.90% | ￥469.00 |
7 | - | - | - | - |
|
S86342-25mg促销 |
99.90% | ￥1080.00 ￥864.00 |
7 | - | - | - | - |
|
S86342-50mg促销 |
99.90% | ￥1700.00 ￥1360.00 |
6 | - | - | - | - |
|
S86342-100mg促销 |
99.90% | ￥2780.00 ￥2220.00 |
4 | - | - | - | - |
|
| 产品描述： | K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Eg5:1.3 μM (IC50);Apoptosis;Kinesin | ||||||||||||||||||||
| 体内研究： | K858 (50, 150 mg/kg, p.o.) shows antitumor activity in an A2780 ovarian cancer xenograft model, also inhibits tumor grwoth in a HCT116 colon cancer xenograft model via 100 mg/kg twice a day orally for 5 days. K858 (100 mg/kg, p.o., qd ×5) displays no neurotoxic side effects in mice | ||||||||||||||||||||
| 参考文献： | 1. Nakai R, et al. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 2009 May 1;69(9):3901-9. 2. De Iuliis F, et al. The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Invest New Drugs. 2016 Aug;34(4):399-406. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | RT，避光 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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