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产品描述： AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s |
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靶点：
GPR119;GPR |
体内研究：
AR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide |
参考文献：
1. Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. 2. J Gao, et al. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplant Proc. 2011 Nov;43(9):3217-20. |
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溶解性：
Soluble in DMSO |
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保存条件：
2-8℃ |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
1.978 ml |
9.891 ml |
19.781 ml |
| 5 mM |
0.396 ml |
1.978 ml |
3.956 ml |
| 10 mM |
0.198 ml |
0.989 ml |
1.978 ml |
| 50 mM |
0.04 ml |
0.198 ml |
0.396 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京