| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86392-10mg促销 |
97% | ￥180.00 ￥162.00 |
10 | 3 | - | - | - |
|
S86392-5mg促销 |
97% | ￥412.00 ￥370.00 |
货期：3-5天 | - | - | - | - |
|
S86392-50mg促销 |
97% | ￥672.00 ￥604.00 |
8 | 3 | - | - | - |
|
S86392-25mg促销 |
97% | ￥755.00 ￥679.00 |
货期：3-5天 | - | - | - | - |
|
S86392-100mg促销 |
97% | ￥1220.00 ￥1100.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1] | ||||||||||||||||||||
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| 靶点： | IC50: 0.53 μM (tubulin polymerization);MicrotubuleAssociated | ||||||||||||||||||||
| 体内研究： | D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model. D-64131 has oral bioavailability and is well tolerated at efficacious doses. Animal Model: Outbred nude mice (6-8 weeks), human amelanoic melanoma MEXF 989 tumor xenograft model Dosage: 200 mg/kg, 400 mg/kg Administration: Oral administration, daily, on days 1-5, 8-9, and 15-18 after xenograft Result: Resulted in significant tumor growth inhibition during treatment. | ||||||||||||||||||||
| 参考文献： | 1. Thomas Beckers, et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119. 2. S Mahboobi, et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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