| 产品描述： | Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function |
| 靶点： |
ROS; mitochondrial function;ReactiveOxygenSpecies;MitochondrialMetabolism |
| 体外研究： |
Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death. Cell Viability Assay Cell Line: Human endothelial cells (HMEC-1) Concentration: 100 μM and10 mM Incubation Time: 100 μM for 24 h, 10 mM for 4 h Result: Prevention of cell death. |
| 体内研究： |
Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance. Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old) Dosage: 200 mg/kg Administration: Oral gavage; b.i.d.; 6 weeks Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment. |
| 参考文献： |
1. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64. 2. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072. |
| 溶解性： |
Soluble in DMSO、H2O |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
5.218 ml |
26.088 ml |
52.175 ml |
| 5 mM |
1.044 ml |
5.218 ml |
10.435 ml |
| 10 mM |
0.522 ml |
2.609 ml |
5.218 ml |
| 50 mM |
0.104 ml |
0.522 ml |
1.044 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京