货号	规格	价格	上海	北京	珠海	重庆	武汉
S86523-2mg	≥99%	￥2200.00 S86523-2mg ￥2200.00 2-3天	0 货期：2-3天	-	-	-	-
S86523-5mg	≥99%	￥3750.00 S86523-5mg ￥3750.00 2-3天	0 货期：2-3天	-	-	-	-
S86523-10mg	≥99%	￥6500.00 S86523-10mg ￥6500.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research

靶点：

Prostaglandin Receptor;Endogenous Metabolite

体内研究：

Iloprost (0.3 mg/kg/min; via s.c. mini pumps; 33 d) has a significant anti-metastatic activity in a spontaneously metastasizing tumor model in rat. Iloprost (0.2 mg/kg/d; i.p.; 10 d) attenuates hyperoxia effects and reduces inflammation in the newborn mouse lung, with Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment. Iloprost (0.2 mg/kg; i.v. or i.p.) exhibits short half-life, and is often administered by means of frequent (every 2-4h) inhalation in treatment Animal Model: Spontaneously metastasizing R 3327 MAT Lu prostate carcinoma in Cop rat Dosage: 0.3 mg/kg/min Administration: Subcutaneous administration via Alzet mini pumps; continuously for 33 days Result: Reduced the number of visible lung metastases, but had no effect on the growth of the primary tumor.This action was based on the ability to reduce the attachment of tumor cells to platelets and to inhibit adhesion of tumor cells-platelet aggregates to the endothelial lining.

参考文献：

1. Kowalczyk-Zieba I, et al. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. 2020 Nov;157:286-296. 2. Hildebrand M. Pharmacokinetics of iloprost and cicaprost in mice. Prostaglandins. 1992 Nov;44(5):431-42. 3. Olave N, et al. Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L535-L544. 4. Schneider MR, et al. Effects of prostacyclin analogues in in vivo tumor models. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:901-8.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.774 ml	13.87 ml	27.74 ml
5 mM	0.555 ml	2.774 ml	5.548 ml
10 mM	0.277 ml	1.387 ml	2.774 ml
50 mM	0.055 ml	0.277 ml	0.555 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

计算重置

ILOPROST