DM4

    
98%

DM4

源叶(MedMol)
S86545 一键复制产品信息
796073-69-3
C38H54ClN3O10S
780.3674
货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
S86545-1mg 98% ¥98.00 9 - - -
S86545-5mg 98% ¥380.00 5 - - -
S86545-10mg 98% ¥620.00 6 - - -
S86545-50mg 98% ¥2100.00 预计交期:2-3天 - - -
S86545-100mg 98% ¥3950.00 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.

产品描述: DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
靶点: Microtubule/Tubulin;ADC Cytotoxin;MicrotubuleAssociated
体外研究: DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death
参考文献: 1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.281 ml 6.407 ml 12.814 ml
5 mM 0.256 ml 1.281 ml 2.563 ml
10 mM 0.128 ml 0.641 ml 1.281 ml
50 mM 0.026 ml 0.128 ml 0.256 ml
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参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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