| 产品描述: | Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) |
| 靶点: |
Adrenergic Receptor |
| 体内研究: |
Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing. Animal Model: Male Wistar rats (250-450 g). Dosage: 10 mg/kg Administration: Oral administration; single. Result: Increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration. |
| 参考文献: |
1. Martin DJ, et al. Relationship between the effects of alfuzosin on rat urethral and blood pressures and its tissue concentrations. Life Sci. 1998;63(3):169-76. 2. Wilde MI, et al. Alfuzosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in benign prostatic hyperplasia. Drugs. 1993 Mar;45(3):410-29. |
| 溶解性: |
Soluble in DMSO |
| 保存条件: |
-20°C |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.568 ml |
12.839 ml |
25.677 ml |
| 5 mM |
0.514 ml |
2.568 ml |
5.135 ml |
| 10 mM |
0.257 ml |
1.284 ml |
2.568 ml |
| 50 mM |
0.051 ml |
0.257 ml |
0.514 ml |
|
| 注意: |
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