货号	规格	价格	上海	北京	珠海	重庆	武汉
S86597-5mg促销	99.20%	￥1190.00 ￥952.00 S86597-5mg ￥952.00 现货	4 4	-	-	-	-
S86597-10mg促销	99.20%	￥1730.00 ￥1380.00 S86597-10mg ￥1380.00 现货	6 6	-	-	-	-
S86597-25mg促销	99.20%	￥3120.00 ￥2490.00 S86597-25mg ￥2490.00 现货	5 5	-	-	-	-

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产品描述：

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC50 of 0.6 μM.

靶点：

IC50: 0.6 μM (HCV replication);HCVProtease

体外研究：

PSI-6130 exhibits potent and specific inhibitory activity against HCV RNA replication mediated by the NS5B polymerase. Both PSI-6130 inhibit HCV GT-1b (Con1 strain) and GT-1a (H77 strain) subgenomic RNA replication, with mean EC50 values of 0.51 and 0.30 μM, respectively. PSI-6130 inhibits 40% human serum with EC50 of 0.51 μM. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC50 of 0.13 μM and Ki of 0.023 μM

参考文献：

1. Ali S, et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob Agents Chemother. 2008 Dec;52(12):4356-69. 2. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):298

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.858 ml	19.288 ml	38.576 ml
5 mM	0.772 ml	3.858 ml	7.715 ml
10 mM	0.386 ml	1.929 ml	3.858 ml
50 mM	0.077 ml	0.386 ml	0.772 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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