| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86605-5mg买3赠1 |
99.40% | ￥300.00 |
>10 | - | - | - | - |
|
S86605-10mg买3赠1 |
99.40% | ￥400.00 |
>10 | - | - | - | - |
|
S86605-25mg买3赠1 |
99.40% | ￥740.00 |
>10 | - | - | - | - |
|
S86605-50mg买3赠1 |
99.40% | ￥1250.00 |
>10 | - | - | - | - |
|
| 产品描述： | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine |
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| 靶点： | TRPV1;TRP/TRPVChannel | ||||||||||||||||||||
| 体内研究： | JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression. JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner. Animal Model: Male Sprague-Dawley rats (260-300 g) Dosage: 0.3 mg/kg Administration: Intravenous injection Result: Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS. | ||||||||||||||||||||
| 参考文献： | 1. Xingjuan Chen, et al. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.J Biol Chem. 2014 Apr 4; 289(14): 9600-9610. 2. Jannis E Meents, et al. Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J Headache Pain. 2015; 16: 57. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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