货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S86715-5mg买3赠1	99.60%	￥2620.00 S86715-5mg ￥2620.00 现货（买3赠1）	10 10	-	-	-	-
S86715-10mg买3赠1	99.60%	￥3750.00 S86715-10mg ￥3750.00 现货（买3赠1）	11 >10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S86715-5mg买3赠1

99.60%

￥2620.00

S86715-10mg买3赠1

99.60%

￥3750.00

>10

产品描述：

(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.

靶点：

SIRT1：98 nM (IC50);Sirtuin

体内研究：

(S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group

参考文献：

1. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. 2. Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. 3. Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. 4. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.021 ml	20.104 ml	40.207 ml
5 mM	0.804 ml	4.021 ml	8.041 ml
10 mM	0.402 ml	2.01 ml	4.021 ml
50 mM	0.08 ml	0.402 ml	0.804 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(4篇)

4. [IF=6.3] Qian Huang et al."Astragalin Inhibits Oxidative Stress-Induced Pyroptosis and Apoptosis in Mouse Models of Renal Ischemia/Reperfusion Injury by Activating the SIRT1/Nrf2 Pathway."PHYTOTHERAPY RESEARCH.2025 Sep;: 3. [IF=4.2] Decheng Meng et al."Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Aug;977:176737 2. [IF=2] Xu Yanmei et al."Astragalus polysaccharide attenuates diabetic nephropathy by reducing apoptosis and enhancing autophagy through activation of Sirt1/FoxO1 pathway."INTERNATIONAL UROLOGY AND NEPHROLOGY".2024 Apr;:1-12 1. [IF=4.36] Pin Gong et al."Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway."J Ethnopharmacol. 2021 Dec;281:114558

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

EX-527(S-enantiomer)

EX527

参考文献(4篇)

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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