货号	规格	价格	上海	北京	珠海	重庆	武汉
S86795-5mg	≥99%	￥850.00 S86795-5mg ￥850.00 3-5天	0 货期：3-5天	-	-	-	-
S86795-10mg	≥99%	￥1500.00 S86795-10mg ￥1500.00 3-5天	0 货期：3-5天	-	-	-	-
S86795-50mg	≥99%	￥4500.00 S86795-50mg ￥4500.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders

靶点：

GPR119

体外研究：

PSN632408 produces concentration-dependent increases in cAMP level with mean EC50 value of 1.9 uM. PSN632408 stimulates β cell replication in cultured mouse islets

体内研究：

PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats. Animal Model: Diet-induced obese (DIO) rats Dosage: 100 mg/kg Administration: P.o.; daily for 14 days Result: The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss

参考文献：

1. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. 2. Gao J, et al. Stimulating beta cell replication and improving islet graft function by GPR119 agonists. Transpl Int. 2011;24(11):1124-1134.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.775 ml	13.873 ml	27.746 ml
5 mM	0.555 ml	2.775 ml	5.549 ml
10 mM	0.277 ml	1.387 ml	2.775 ml
50 mM	0.055 ml	0.277 ml	0.555 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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