| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86833-5mg买3赠1 |
99.80% | ￥520.00 |
>10 | - | - | - | - |
|
S86833-10mg买3赠1 |
99.80% | ￥820.00 |
9 | - | - | - | - |
|
S86833-50mg促销 |
99.80% | ￥2250.00 ￥1800.00 |
6 | - | - | - | - |
|
S86833-100mg促销 |
99.80% | ￥3370.00 ￥2690.00 |
4 | - | - | - | - |
|
| 产品描述： | Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC50 of 200 nM. | ||||||||||||||||||||
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| 靶点： | Eg5:200 nM (IC50);Kinesin | ||||||||||||||||||||
| 体内研究： | Dimethylenastron (1.0 µmol) induces a milder scarring but the length of bleb survival is not significantly prolonged compared with the control group. Dimethylenastron (1.0 µmol) reveals a markedly reduced ratio of intraocular pressure and a milder, but not obviously reduced, subconjunctival fibrotic reaction in the rabbits treated with glaucoma filtration surgery | ||||||||||||||||||||
| 参考文献： | 1. Gartner M, et al. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. Chembiochem. 2005 Jul;6(7):1173-7. 2. Sun XD, et al. Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta Pharmacol Sin. 2011 Dec;32(12):1543-8. 3. Lüke J, et al. The effect of adjuvant dimethylenastron, a mitotic Kinesin Eg5 inhibitor, in experimental glaucoma filtration surgery. Curr Eye Res. 2010 Dec;35(12):1090-8. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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