| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86943-1mg促销 |
98% | ￥400.00 ￥360.00 |
10 | - | - | - | - |
|
S86943-5mg促销 |
98% | ￥1300.00 ￥1170.00 |
10 | - | - | - | - |
|
S86943-10mg促销 |
98% | ￥2000.00 ￥1800.00 |
10 | - | - | - | - |
|
S86943-25mg促销 |
98% | ￥4000.00 ￥3600.00 |
10 | - | - | - | - |
|
S86943-50mg促销 |
98% | ￥6300.00 ￥5670.00 |
6 | - | - | - | - |
|
S86943-100mg促销 |
98% | ￥8800.00 ￥7920.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | ROCKII:12 nM (IC50);CaMKII:0.18 μM (IC50);PKG:0.36 μM (IC50);AuroraA:0.745 μM (IC50);PKA:3.03 μM (IC50);Src:3.06 μM (IC50);PKC:5.68 μM (IC50);Abl:7.77 μM (IC50);MKK4:16.9 μM (IC50);MLCK:28.3 μM (IC50);EGFR:50 μM (IC50);GSK3α:60.7 μM (IC50);AMPK:100 μM (IC50);P38α:100 μM (IC50);ROCK | ||||||||||||||||||||
| 参考文献： | 1. Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12. 2. Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16. 3. Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169(2):855-62. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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