| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S86959-1mg |
99.3% | ￥120.00 | 5 | - | - | - |
|
S86959-2mg |
99.3% | ￥180.00 | 5 | - | - | - |
|
S86959-5mg |
99.3% | ￥270.00 | 4 | - | - | - |
|
S86959-10mg |
99.3% | ￥370.00 | 6 | - | - | - |
|
S86959-25mg |
99.3% | ￥560.00 | 6 | - | - | - |
|
S86959-50mg |
≥99% | ￥1000.00 | 货期：2-3天 | - | - | - |
|
S86959-100mg |
≥99% | ￥1800.00 | 货期：2-3天 | - | - | - |
|
AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect
| 产品描述： | AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect | ||||||||||||||||||||
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| 靶点： | IC50: 21.58 nM (Ack1);ACK | ||||||||||||||||||||
| 体内研究： | In male nude castrated mice, AIM-100 (4 mg/kg) suppresses growth of radioresistant castration-resistant prostate cancer (CRPC) xenograft tumors by decreasing ataxia-telangiectasia mutated kinase (ATM) expression | ||||||||||||||||||||
| 参考文献： | 1. Mahajan K, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012 Apr;180(4):1386-93. 2. Mahajan K, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun 22;287(26):22112-22. 3. Mahajan K, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010 Sep 1;70(12):1274-85. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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