| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87036-1mg |
≥99% | ￥370.00 |
货期：3-5天 | - | - | - | - |
|
S87036-5mg |
≥99% | ￥990.00 |
货期：3-5天 | - | - | - | - |
|
S87036-10mg |
≥99% | ￥1560.00 |
货期：3-5天 | - | - | - | - |
|
S87036-50mg |
≥99% | ￥4700.00 |
货期：3-5天 | - | - | - | - |
|
S87036-100mg |
≥99% | ￥6500.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment | ||||||||||||||||||||
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| 靶点： | RET;c-RET | ||||||||||||||||||||
| 体外研究： | NVP-BBT594 blocks the GDNF-mediated enhancement of MCF7-LTED cell viability in 2D culture and 3D colony formation. The addition of 10 pM E2, to mimic the E2 level in post-menopausal patients that have relapsed on AI treatment and ceased AI therapy, increases 3D colony formation of both MCF7 and MCF7-LTED cells, and this effect is efficiently reverted by NVP-BBT594. Parental T47D cells cultured in presence of low level E2, GFRα1/GDNF stimulation results in increased 3D colony formation, which is significantly reverted by NVP-BBT594. NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment. NVP-BBT594 impairs GDNF-mediated RET downstream signaling and significantly enhances the antiproliferative effects of letrozole. NVP-BBT594 shows the highest suppression of GDNF-induced RET signaling, as assessed by RET, ERK1/2, AKT and ER phosphorylation. NVP-AST487 and NVP-BBT594 have comparable RET inhibitory activity in wild-type MCF7 cells | ||||||||||||||||||||
| 参考文献： | 1. Morandi A, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 2013 Jun 15;73(12):3783-95 2. Andreucci E, et al. Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts. Oncotarget. 2016 Sep 2. doi: 10.18632/oncotarget.11826.[Epub ahead of print] | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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