货号	规格	价格	上海	北京	珠海	重庆	武汉
S87040-5mg买3赠1	99.34%	￥190.00 S87040-5mg ￥190.00 现货（买3赠1）	8 8	-	-	-	-
S87040-10mg买3赠1	99.34%	￥340.00 S87040-10mg ￥340.00 现货（买3赠1）	3 3	-	-	-	-
S87040-25mg买3赠1	99.34%	￥518.00 S87040-25mg ￥518.00 现货（买3赠1）	3 3	-	-	-	-
S87040-50mg买3赠1	99.34%	￥840.00 S87040-50mg ￥840.00 现货（买3赠1）	6 6	-	-	-	-
S87040-100mg买3赠1	99.34%	￥1150.00 S87040-100mg ￥1150.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

靶点：

Oligomeric aggregates are presumed to be the key neurotoxic agent. Emrusolmin blocksthe formation of pathological aggregates of prion protein and of α-synuclein, which is deposited in Parkinson’s disease and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Emrusolmin strongly inhibits all prion strains tested including BSE-derived and human prions. Emrusolmin shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oli

体外研究：

Emrusolmin shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oligomers in vitro and in vivo both for prion protein and α-synuclein. Emrusolmin (0.6-2 g/kg; p.o.) modulates α‐synuclein oligomerization. Animal Model: Two‐month‐old PLP‐hαSyn mice Dosage: 0.6 and 2 g/kg Administration: Oral Result: Prevented motor deficits and neurodegeneration in the PLP‐hαSyn mice.

体内研究：

Emrusolmin 显示出与病理聚集体的结构依赖性结合，并在体外和体内强烈抑制朊病毒蛋白和 α-突触核蛋白病理寡聚体的形成。
Emrusolmin (0.6-2 g/kg；口服) 调节 α-突触核蛋白寡聚化。

参考文献：

1. Wagner J, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 Jun;125(6):795-813. 2. Martinez Hernandez A, et al. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Mol Med. 2018;10(1):32-47. 3. Heras-Garvin A, et al. Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov Disord. 2019;34(2):255-263.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.914 ml	14.57 ml	29.14 ml
5 mM	0.583 ml	2.914 ml	5.828 ml
10 mM	0.291 ml	1.457 ml	2.914 ml
50 mM	0.058 ml	0.291 ml	0.583 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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