| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87113-5mg买3赠1 |
99.90% | ￥680.00 |
6 | - | - | - | - |
|
S87113-10mg买3赠1 |
99.90% | ￥1020.00 |
6 | - | - | - | - |
|
S87113-25mg买3赠1 |
99.90% | ￥1980.00 |
6 | - | - | - | - |
|
S87113-100mg买3赠1 |
≥98% | ￥4470.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission | ||||||||||||||||||||
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| 靶点： | Potassium Channel;PotassiumChannel;CalciumChannel;HER | ||||||||||||||||||||
| 体外研究： | VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner with 75 and 100 μM treatments causing a significant reduction in GABA-elicited hyperpolarization while 25 μM had no significant effect. | ||||||||||||||||||||
| 体内研究： | VU 0240551 (10 μM) significantly blocks the chloride influx in cells from Eu rats but did not affect cells from SL rats. | ||||||||||||||||||||
| 参考文献： | 1. Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. 2. Wang Y, et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409. 3. Balapattabi K, et al. Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. J Neuroendocrinol. 2019;31(8):e12752. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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