货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S87139-5mg	≥98%	￥1480.00 S87139-5mg ￥1480.00 3-5天	0 货期：3-5天	-	-	-	-
S87139-10mg	≥98%	￥2390.00 S87139-10mg ￥2390.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy

靶点：

IC50: 0.8 nM (PDE10A), 31.72 μg/mL (DPPH), 16.04 μg/mL (CUPRAC);PDE

体内研究：

TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides. Animal Model: Male CD rats Dosage: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg Administration: Subcutaneous injection; 0.1-10 mg/kg once Result: Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.

参考文献：

1. Hamaguchi W, et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem Pharm Bull (Tokyo). 2014;62(12):1200-1213. 2. Schmidt CJ, et al. Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia. J Pharmacol Exp Ther. 2008 May;325(2):681-90. 3. Kaproń B, et al. 1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy. J Enzyme Inhib Med Chem. 2020 Dec;35(1):993-1002.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.174 ml	10.87 ml	21.739 ml
5 mM	0.435 ml	2.174 ml	4.348 ml
10 mM	0.217 ml	1.087 ml	2.174 ml
50 mM	0.043 ml	0.217 ml	0.435 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

TP-10

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)