| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87145-2mg买3赠1 |
99.70% | ￥272.00 |
8 | - | - | - | - |
|
S87145-5mg买3赠1 |
99.70% | ￥295.00 |
6 | - | - | - | - |
|
S87145-10mg买3赠1 |
99.70% | ￥495.00 |
8 | - | - | - | - |
|
S87145-25mg买3赠1 |
99.70% | ￥1100.00 |
7 | - | - | - | - |
|
S87145-50mg买3赠1 |
99.70% | ￥2000.00 |
2 | - | - | - | - |
|
S87145-100mg促销 |
≥99% | ￥3200.00 ￥2900.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC 50: 210 nM (LYPLA1);Phospholipase | ||||||||||||||||||||
| 体外研究： | ML348 (5 µM; 3 hours ) selectively inhibits LYPLA1 in cultured cells. Cell Viability Assay Cell Line: HEK293T cells, murine T-cells Concentration: 5 µM Incubation Time: 3 hours Result: Show potent, selective inhibition of LYPLA1. | ||||||||||||||||||||
| 体内研究： | ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice. Animal Model: C57BL6 male mice (3-4 months) Dosage: 50 mg/kg Administration: Intraperitoneal injection; 3 hours Result: Potent and selective inhibited LYPLA1 enzymes in heart, kidney and lung in vivo. | ||||||||||||||||||||
| 参考文献： | 1. Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). National Center for Biotechnology Information (US); 2010- 2013 Apr 08. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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