货号	规格	价格	上海	北京	珠海	重庆	武汉
S87149-5mg买3赠1	99.80%	￥430.00 S87149-5mg ￥430.00 现货（买3赠1）	8 8	-	-	-	-
S87149-10mg促销	99.80%	￥690.00 ￥552.00 S87149-10mg ￥552.00 现货	5 5	-	-	-	-
S87149-50mg促销	99.80%	￥2090.00 ￥1670.00 S87149-50mg ￥1670.00 现货	2 2	-	-	-	-

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产品描述：

JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ and EphB4 with potent anti-cancer activity.

靶点：

VEGFR2;PDGFRβ;VEGFR;PDGFR;EphrinReceptor

体内研究：

JI-101excreted through bile along with its mono- and di-hydroxy metabolites. Following oral administration, JI-101 is rapidly absorbed, reaching Cmax within 2 h. The t1/2 of JI-101 with intravenous and oral route is found to be 1.75±0.79 and 2.66±0.13 h, respectively. The Cl and Vd by intravenous route for JI-101 are found to be 13.0±2.62 mL/min/kg and 2.11±1.42 L/kg, respectively. The tissue distribution of JI-101 is extensive with rapid and preferred uptake into lung tissue. Overall, the oral bioavailability of JI-101 is 55% and the primary route of elimination for JI-101 is feces

参考文献：

1. Gurav SD, et al. Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats. Arzneimittelforschung. 2012 Jan;62(1):27-34.

溶解性：

Soluble in DMSO

保存条件：

-20°C，避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.144 ml	10.722 ml	21.444 ml
5 mM	0.429 ml	2.144 ml	4.289 ml
10 mM	0.214 ml	1.072 ml	2.144 ml
50 mM	0.043 ml	0.214 ml	0.429 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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