货号	规格	价格	上海	北京	珠海	重庆	武汉
S87159-5mg买3赠1	98.10%	￥750.00 S87159-5mg ￥750.00 现货（买3赠1）	5 5	-	-	-	-
S87159-10mg促销	98.10%	￥1140.00 ￥912.00 S87159-10mg ￥912.00 现货	6 6	-	-	-	-
S87159-25mg促销	98.10%	￥2130.00 ￥1700.00 S87159-25mg ￥1700.00 现货	5 5	-	-	-	-
S87159-100mg促销	≥98%	￥4240.00 ￥3390.00 S87159-100mg ￥3390.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

NVP-LCQ195 (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).

靶点：

CDK

体外研究：

NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-1 mol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4.

体内研究：

Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells.

参考文献：

1. McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.172 ml	10.862 ml	21.724 ml
5 mM	0.434 ml	2.172 ml	4.345 ml
10 mM	0.217 ml	1.086 ml	2.172 ml
50 mM	0.043 ml	0.217 ml	0.434 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

NVP-LCQ195

4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)