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NVP-LCQ195

    
98.10%

4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide

源叶(MedMol)
S87159 一键复制产品信息
902156-99-4
C17H19Cl2N5O4S
460.33
NVP-LCQ-195; NVP-LCQ 195; NVP-LCQ195. LCQ-195; LCQ 195; LCQ195; AT9311; AT-9311; AT 9311.
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87159-5mg买3赠1
98.10%

¥750.00

5 - - - -
S87159-10mg促销
98.10%

¥1140.00 ¥912.00

6 - - - -
S87159-25mg促销
98.10%

¥2130.00 ¥1700.00

5 - - - -
S87159-100mg促销
≥98%

¥4240.00 ¥3390.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: NVP-LCQ195 (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
靶点: CDK
体外研究: NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-1 mol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4.
体内研究: Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells.
参考文献: 1. McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.172 ml 10.862 ml 21.724 ml
5 mM 0.434 ml 2.172 ml 4.345 ml
10 mM 0.217 ml 1.086 ml 2.172 ml
50 mM 0.043 ml 0.217 ml 0.434 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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