货号	规格	价格	上海	北京	珠海	重庆	武汉
S87180-5mg买3赠1	99.40%	￥88.00 S87180-5mg ￥88.00 现货（买3赠1）	806 >10	-	-	-	-
S87180-10mg买3赠1	99.40%	￥160.00 S87180-10mg ￥160.00 现货（买3赠1）	406 >10	-	-	-	-
S87180-25mg买3赠1	99.40%	￥272.00 S87180-25mg ￥272.00 现货（买3赠1）	168 >10	-	-	-	-
S87180-50mg买3赠1	99.40%	￥456.00 S87180-50mg ￥456.00 现货（买3赠1）	87 >10	-	-	-	-
S87180-100mg买3赠1	99.40%	￥632.00 S87180-100mg ￥632.00 现货（买3赠1）	47 >10	-	-	-	-
S87180-200mg买3赠1	99.40%	￥840.00 S87180-200mg ￥840.00 现货（买3赠1）	26 >10	-	-	-	-

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产品描述：

Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.

靶点：

IC50: 0.49 μM (PDE4);PDE

体内研究：

Crisaborole (AN-2728) shows significant inhibition against the ear edema caused by phorbol ester after dosing at 1 mg/ear×2 (78% and 68%, respectively). The efficacy is comparable to that of dexamethasone, suggesting that Crisaborole (AN-2728) has good anti-inflammatory activity as well as skin penetration. Crisaborole (AN-2728) is reported to be well tolerated and to demonstrate significant effects on markers of efficacy, with results that are comparable to positive controls in clinical trials

参考文献：

1. Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32. 2. Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.983 ml	19.916 ml	39.833 ml
5 mM	0.797 ml	3.983 ml	7.967 ml
10 mM	0.398 ml	1.992 ml	3.983 ml
50 mM	0.08 ml	0.398 ml	0.797 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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