货号	规格	价格	上海	北京	珠海	重庆	武汉
S87210-10mg	≥98%(HPLC)	￥178.00 S87210-10mg ￥178.00 现货	10 0 10	-	-	-	-
S87210-50mg	≥98%(HPLC)	￥538.00 S87210-50mg ￥538.00 现货	10 10	-	-	-	-
S87210-100mg	≥98%(HPLC)	￥988.00 S87210-100mg ￥988.00 现货	9 9	-	-	-	-
S87210-250mg	≥98%(HPLC)	￥1880.00 S87210-250mg ￥1880.00 现货	4 4	-	-	-	-

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产品描述：

Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.

靶点：

PARP-2:2.9 nM (Ki);PARP-1:5.2 nM (Ki);PARP;Autophagy

体内研究：

The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time

参考文献：

1. Donawho CK, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37. 2. Penning TD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23. 3. Albert JM, et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 2007 May 15;13(10):3033-42. 4. Robert J. Kinders, et al. Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts. Clin Cancer Res. Author manuscript; available in PMC 2009 Nov 1.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.152 ml	15.762 ml	31.525 ml
5 mM	0.63 ml	3.152 ml	6.305 ml
10 mM	0.315 ml	1.576 ml	3.152 ml
50 mM	0.063 ml	0.315 ml	0.63 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Veliparib dihydrochloride,PARP-1和-2抑制剂

Veliparib dihydrochloride

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)