货号	规格	价格	上海	北京	珠海	重庆	武汉
S87242-1mg买3赠1	99.60%	￥180.00 S87242-1mg ￥180.00 现货（买3赠1）	9 9	-	-	-	-
S87242-5mg买3赠1	99.60%	￥440.00 S87242-5mg ￥440.00 现货（买3赠1）	9 9	-	-	-	-
S87242-10mg买3赠1	99.60%	￥700.00 S87242-10mg ￥700.00 现货（买3赠1）	11 >10	-	-	-	-
S87242-50mg买3赠1	99.60%	￥2170.00 S87242-50mg ￥2170.00 现货（买3赠1）	7 7	-	-	-	-
S87242-100mg买3赠1	99.60%	￥3160.00 S87242-100mg ￥3160.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 Μm

靶点：

IC50: 0.5 μM (sFRP-1)

体内研究：

WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC50 of about 1 nM. WAY-316606 has good aqueous solubility, moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2>60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration

参考文献：

1. Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116. 2. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.23 ml	11.149 ml	22.298 ml
5 mM	0.446 ml	2.23 ml	4.46 ml
10 mM	0.223 ml	1.115 ml	2.23 ml
50 mM	0.045 ml	0.223 ml	0.446 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

WAY 316606

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)