货号	规格	价格	上海	北京	珠海	重庆	武汉
S87253-5mg促销	≥98%	￥250.00 ￥225.00 S87253-5mg ￥225.00 现货	10 10	-	-	-	-
S87253-10mg促销	≥98%	￥400.00 ￥360.00 S87253-10mg ￥360.00 现货	6 6	-	-	-	-
S87253-25mg促销	≥98%	￥800.00 ￥720.00 S87253-25mg ￥720.00 现货	4 4	-	-	-	-
S87253-50mg促销	≥98%	￥1600.00 ￥1440.00 S87253-50mg ￥1440.00 现货	2 2	-	-	-	-
S87253-100mg促销	≥98%	￥2400.00 ￥2160.00 S87253-100mg ￥2160.00 现货	1 1	-	-	-	-

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产品描述：

Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep.

靶点：

GABA Receptor;GABAReceptor

体内研究：

In vivo, Lorediplon inhibits spontaneous motor activity and increases the duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow-wave sleep (SWS) and paradoxical sleep (PS) in mice

参考文献：

1. Anaclet C, et al. Effects of GF-015535-00, a novel α1 GABA A receptor ligand, on the sleep-wake cycle in mice, with reference to zolpidem. Sleep. 2012 Jan 1;35(1):103-11. 2. Horoszok L, et al. A single-dose, randomized, double-blind, double dummy, placebo and positive-controlled, five-way cross-over study to assess the pharmacodynamic effects of lorediplon in a phase advance model of insomnia in healthy Caucasian adult male subjects. Hum Psychopharmacol. 2014 May;29(3):266-73.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.535 ml	12.677 ml	25.354 ml
5 mM	0.507 ml	2.535 ml	5.071 ml
10 mM	0.254 ml	1.268 ml	2.535 ml
50 mM	0.051 ml	0.254 ml	0.507 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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