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Lorediplon

    
≥98%

Lorediplon

源叶(MedMol)
S87253 一键复制产品信息
917393-39-6
C20H15FN4O2S
394.4221
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87253-5mg促销
≥98%

¥250.00 ¥225.00

10 - - - -
S87253-10mg促销
≥98%

¥400.00 ¥360.00

6 - - - -
S87253-25mg促销
≥98%

¥800.00 ¥720.00

4 - - - -
S87253-50mg促销
≥98%

¥1600.00 ¥1440.00

2 - - - -
S87253-100mg促销
≥98%

¥2400.00 ¥2160.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep.
靶点: GABA Receptor;GABAReceptor
体内研究: In vivo, Lorediplon inhibits spontaneous motor activity and increases the duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow-wave sleep (SWS) and paradoxical sleep (PS) in mice
参考文献: 1. Anaclet C, et al. Effects of GF-015535-00, a novel α1 GABA A receptor ligand, on the sleep-wake cycle in mice, with reference to zolpidem. Sleep. 2012 Jan 1;35(1):103-11. 2. Horoszok L, et al. A single-dose, randomized, double-blind, double dummy, placebo and positive-controlled, five-way cross-over study to assess the pharmacodynamic effects of lorediplon in a phase advance model of insomnia in healthy Caucasian adult male subjects. Hum Psychopharmacol. 2014 May;29(3):266-73.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.535 ml 12.677 ml 25.354 ml
5 mM 0.507 ml 2.535 ml 5.071 ml
10 mM 0.254 ml 1.268 ml 2.535 ml
50 mM 0.051 ml 0.254 ml 0.507 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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