| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87275-5mg促销 |
97% | ￥569.00 ￥450.00 |
10 | - | - | - | - |
|
S87275-10mg促销 |
97% | ￥1010.00 ￥800.00 |
10 | - | - | - | - |
|
S87275-25mg促销 |
97% | ￥2060.00 ￥1640.00 |
9 | - | - | - | - |
|
S87275-50mg促销 |
97% | ￥3500.00 ￥2800.00 |
10 | - | - | - | - |
|
S87275-100mg促销 |
97% | ￥5950.00 ￥4760.00 |
5 | - | - | - | - |
|
| 产品描述： | Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively[1] | ||||||||||||||||||||
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| 靶点： | IC50: 1.96 µM (HCN channels);HCNChannel | ||||||||||||||||||||
| 体内研究： | Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia. Animal Model: Male C57/Bl6-mice Dosage: 0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg Administration: Intraperitoneal injection; for 30 minutes Result: Observed acute blood glucose reduction, dose-dependently reduced glycated hemoglobin, significantly prevented the decrease of IRI levels at doses of 3 and 10 mg/kg, and no difference in food intake or body weight. | ||||||||||||||||||||
| 参考文献： | 1. Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006 Apr;69(4):1328-37. Epub 2005 Dec 30. 2. Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃;干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京