货号	规格	价格	上海	北京	珠海	重庆	武汉
S87290-1mg买3赠1	99.30%	￥50.00 S87290-1mg ￥50.00 现货（买3赠1）	7 7	-	-	-	-
S87290-2mg买3赠1	99.30%	￥90.00 S87290-2mg ￥90.00 现货（买3赠1）	8 8	-	-	-	-
S87290-5mg买3赠1	99.30%	￥100.00 S87290-5mg ￥100.00 现货（买3赠1）	8 8	-	-	-	-
S87290-10mg买3赠1	99.30%	￥140.00 S87290-10mg ￥140.00 现货（买3赠1）	6 6	-	-	-	-
S87290-25mg买3赠1	99.30%	￥320.00 S87290-25mg ￥320.00 现货（买3赠1）	4 4	-	-	-	-
S87290-50mg促销	99.30%	￥580.00 ￥464.00 S87290-50mg ￥464.00 现货	5 5	-	-	-	-
S87290-100mg促销	99.30%	￥790.00 ￥632.00 S87290-100mg ￥632.00 现货	5 5	-	-	-	-

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产品描述：

Valrocemide (TV1901) is a promising antiepileptic drug candidate that shows a broad spectrum of anticonvulsant activity.

体内研究：

In mice, valrocemide affords complete protection against maximal electroshock-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz “psychomotor” seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively. Valrocemide is also effective in preventing sound-induced seizures in Frings audiogenic-seizure susceptible mice (ED50, 52 mg/kg). The median neurotoxic dose in mice is 332 mg/kg. After oral administration to rats, valrocemide is active in the MES test, with an ED50 of 73 mg/kg, and the median neurotoxic dose is 1,000 mg/kg. Intraperitoneal administration of 300 mg/kg of valrocemide to hippocampal kindled Sprague–Dawley rats block generalized seizures and shorten the afterdischarge duration significantly. Valrocemide also provides complete protection from focal seizures in the corneally kindled rats (ED50, 161 mg/kg)

参考文献：

1. Isoherranen N, et al. Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. Epilepsia. 2001 Jul;42(7):831-6.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.993 ml	24.965 ml	49.93 ml
5 mM	0.999 ml	4.993 ml	9.986 ml
10 mM	0.499 ml	2.497 ml	4.993 ml
50 mM	0.1 ml	0.499 ml	0.999 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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VALROCEMIDE