货号	规格	价格	上海	北京	珠海	重庆	武汉
S87295-5mg买3赠1	99.10%	￥470.00 S87295-5mg ￥470.00 现货（买3赠1）	5 5	-	-	-	-
S87295-10mg买3赠1	99.10%	￥700.00 S87295-10mg ￥700.00 现货（买3赠1）	4 4	-	-	-	-
S87295-25mg促销	99.10%	￥1410.00 ￥1120.00 S87295-25mg ￥1120.00 现货	5 5	-	-	-	-

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产品描述：

Opicapone (BIA 9-1067) is a potent third-generation catechol-O-methyltransferase (COMT) inhibitor for the research of Parkinson's disease and motor fluctuations. Opicapone decreases the ATP content of the cells with an IC50 of 98 μM

靶点：

COMT;Transferase

体内研究：

Opicapone inhibits rat peripheral COMT with ED50 values below 1.4 mg/kg up to 6 h post-administration. The effect is sustained over the first 8 h and by 24 h COMT had not returned to control values. A single administration of Opicapone resulted in increased and sustained plasma L-DOPA levels with a concomitant reduction in 3-OMD from 2 h up to 24 h post-administration, while Ro 40-7592 produces significant effects only at 2 h post-administration. The effects of Opicapone on brain catecholamines after L-DOPA administration are sustained up to 24 h post-administration. Opicapone is also the least potent compound in decreasing both the mitochondrial membrane potential and the ATP content in human primary hepatocytes after a 24 h incubation period

参考文献：

1. Bonifácio MJ, et al. Pharmacological profile of Opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. Br J Pharmacol. 2015 Apr;172(7):1739-52. 2. Ferreira JJ, et al. Opicapone as an adjunct to L-DOPA in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial. Lancet Neurol. 2016 Feb;15(2):154-165.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.42 ml	12.102 ml	24.203 ml
5 mM	0.484 ml	2.42 ml	4.841 ml
10 mM	0.242 ml	1.21 ml	2.42 ml
50 mM	0.048 ml	0.242 ml	0.484 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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