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Eliglustat (hemitartrate)

    
99.40%

Eliglustat (hemitartrate)

源叶(MedMol)
S87332 一键复制产品信息
928659-70-5
C50H78N4O14
959.1727
Eliglustat hemitartrate
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S87332-1mg买3赠1
99.40%

¥230.00

>10 - - - -
S87332-5mg买3赠1
99.40%

¥420.00

>10 - - - -
S87332-10mg买3赠1
99.40%

¥650.00

10 - - - -
S87332-100mg促销
99.40%

¥1030.00 ¥824.00

7 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Eliglustat hemitartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM
靶点: IC50: 24 nM (glucocerebroside synthase)
体外研究: Eliglustat tartrate shows good potency with an IC50 of 24 nM and specificity against the target enzyme.Incubating K562 or B16/F10 cells for 72 h with increasing amounts of Genz-112638 (0.6-1000 nM) results in a dose-dependent reduction of cell surface levels of both GM1 and GM3. The mean IC50 value for inhibiting the cell surface presentation of GM1 in K562 cells was 24 nM (range 14-34 nM) and that for GM3 in B16/F10 cells was 29 nM (range 12-48 nM)
体内研究: Mice that received drug prior to significant accumulation of substrate (10 weeks of age) showed reduced levels of glucosylceramide and number of Gaucher cells in the spleen, lung and liver when compared to age-matched control animals
参考文献: 1. McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-67.
溶解性: Soluble  in  DMSO、H2O
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.043 ml 5.213 ml 10.426 ml
5 mM 0.209 ml 1.043 ml 2.085 ml
10 mM 0.104 ml 0.521 ml 1.043 ml
50 mM 0.021 ml 0.104 ml 0.209 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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