货号	规格	价格	上海	北京	珠海	重庆	武汉
S87359-1mg	≥98%	￥180.00 S87359-1mg ￥180.00 2-3天	0 货期：2-3天	-	-	-	-
S87359-5mg	≥98%	￥500.00 S87359-5mg ￥500.00 现货	9 9	-	-	-	-
S87359-10mg	≥98%	￥860.00 S87359-10mg ￥860.00 现货	15 >10	-	-	-	-
S87359-25mg	≥98%	￥1360.00 S87359-25mg ￥1360.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

靶点：

Sodium channel blocker

体外研究：

Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the US Food and Drug Administration in July 2013.

参考文献：

1. Large CH, et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia. J Pharmacol Exp Ther. 2011 Jul;338(1):100-13.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.851 ml	14.253 ml	28.505 ml
5 mM	0.57 ml	2.851 ml	5.701 ml
10 mM	0.285 ml	1.425 ml	2.851 ml
50 mM	0.057 ml	0.285 ml	0.57 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

计算重置

CNV1014802 (hydrochloride)