货号	规格	价格	上海	北京	珠海	重庆	武汉
S87372-1mg买3赠1	99.80%	￥520.00 S87372-1mg ￥520.00 现货（买3赠1）	5 5	-	-	-	-
S87372-5mg促销	99.80%	￥1080.00 ￥864.00 S87372-5mg ￥864.00 现货	6 6	-	-	-	-
S87372-10mg促销	99.80%	￥1650.00 ￥1320.00 S87372-10mg ￥1320.00 现货	6 6	-	-	-	-
S87372-25mg促销	99.80%	￥2880.00 ￥2300.00 S87372-25mg ￥2300.00 现货	5 5	-	-	-	-
S87372-50mg促销	≥98%	￥4180.00 ￥3340.00 S87372-50mg ￥3340.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. Zabadinostat has no activity against HDAC class II. Zabadinostat has antitumor activity

靶点：

HDAC1:63 nM (IC50);HDAC3:550 nM (IC50);HDAC2:570 nM (IC50);HDAC

体外研究：

Zabadinostat has been tested in vitro in colon, lung, non-Hodgkin lymphoma, and myeloma cell lines with IC50s ranged from 0.2 to 15 μM

体内研究：

Zabadinostat substantially reduces tumor size in murine xenograft lung (A549a) and colon (HT29) models at a dose of 50 mg/kg. Tumor reductions are found to be associated with increased histone acetylation and decreased HDAC enzyme activity. For Zabadinostat, after oral dosing in murine and canine models, peak plasma concentrations (Cmax) are reached 1 to 2 hours after the dose and terminal half‐lives are 6 hours and 8 hours, respectively. After murine oral [14C]-Zabadinostat at a dose of 1.6 mg/kg (4 μmol/kg), tissue radioactivity peaked 3 to 6 hours after the dose and declined slowly thereafter with Zabadinostat‐related material still present in tissue 21 days after the dose

参考文献：

1. Eyre TA, et al. Predictive biomarkers for disease sensitivity in lymphoma - the holy grail for HDAC inhibitors? Oncotarget. 2018 Dec 18;9(99):37280-37281. 2. Eyre TA, et al. A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer. Cancer. 2019 Jan 1;125(1):99-108.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.478 ml	12.391 ml	24.782 ml
5 mM	0.496 ml	2.478 ml	4.956 ml
10 mM	0.248 ml	1.239 ml	2.478 ml
50 mM	0.05 ml	0.248 ml	0.496 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

HDAC-IN-4