货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S87377-5mg	≥98%	￥780.00 S87377-5mg ￥780.00 3-5天	0 货期：3-5天	-	-	-	-
S87377-10mg	≥98%	￥1280.00 S87377-10mg ￥1280.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. IC50 value: 5 nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides) Target: Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties.

参考文献：

1. Kelly E. Desino, Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3 ml	15 ml	30 ml
5 mM	0.6 ml	3 ml	6 ml
10 mM	0.3 ml	1.5 ml	3 ml
50 mM	0.06 ml	0.3 ml	0.6 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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