货号	规格	价格	上海	北京	珠海	重庆	武汉
S87388-5mg	≥94%	￥740.00 S87388-5mg ￥740.00 3-5天	0 货期：3-5天	-	-	-	-
S87388-10mg	≥94%	￥1150.00 S87388-10mg ￥1150.00 3-5天	0 货期：3-5天	-	-	-	-
S87388-50mg	≥94%	￥3130.00 S87388-50mg ￥3130.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

PCI-32765 is an inhibitor of Bruton tyrosine kinase (BTK) with IC50 value of 0.5nM PCI-32765 is a covalent and irreversible inhibitor of BTK through bonding to Cys-481 in the ATP binding domain. PCI-32765 inhibits phosphorylation of BTK in a B cells (IC50 of 11nM) as well as the downstream substrates phosphoinositide phospholipase Cγ (PLC γ) and ERK in cell assays. PCI-32765 has in vivo efficacy in B cell lymphoma. In CLL cells, PCI-32765 induces cells apoptosis through inhibiting the expression of BCR-dependent UDP-glucose ceramide glucosyltransferase. PCI-32765 is oral effective in vivo. It induces lymphocytosis during the first weeks of therapy in patients with CLL. It is also efficacious in autoimmune disease. In the MRL-Fas lupus model, PCI-32765 inhibits collagen-induced arthritis as well as autoantibody production and development of kidney disease. It also diminished FcγRIII-induced production of pro-inflammatory cytokines

参考文献：

1. Burger JA, Buggy JJ. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765). Leuk Lymphoma. 2013 Nov;54(11):2385-91.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.27 ml	11.351 ml	22.702 ml
5 mM	0.454 ml	2.27 ml	4.54 ml
10 mM	0.227 ml	1.135 ml	2.27 ml
50 mM	0.045 ml	0.227 ml	0.454 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

PCI-32765 (Racemate)