货号	规格	价格	上海	北京	珠海	重庆	武汉
S87411-1mg促销	≥97%	￥900.00 ￥720.00 S87411-1mg ￥720.00 3-5天	0 货期：3-5天	-	-	-	-
S87411-5mg促销	≥97%	￥2500.00 ￥2000.00 S87411-5mg ￥2000.00 3-5天	0 货期：3-5天	-	-	-	-
S87411-10mg促销	≥97%	￥3800.00 ￥3040.00 S87411-10mg ￥3040.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

EOC317 (ACTB-1003) is an oral kinase inhibitor with IC50s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2

靶点：

FGFR1:6 nM (IC50);VEGFR2:2 nM (IC50);Tie-2:4 nM (IC50);VEGFR; FGFR; Tie-2

体外研究：

EOC317 (ACTB-1003) is an oral kinase inhibitor with multiple modes of action, targeting cancer mutations via FGFR inhibition FGFR1 (IC50=6 nM), angiogenesis through inhibition of VEGFR2 (2 nM), Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). EOC317 is highly active with dose-dependent tumor growth inhibition in cell lines with FGFR genetic alterations-OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1. OPM2 cells harbor the FGFR3 t(4:14) translocation, FGFR3 K650E mutation and PTEN deletion while the Ba/F3-TEL-FGFR1 cells are driven by FGFR1 over-expression

体内研究：

EOC317 (ACTB-1003) is shown to inhibit tumor angiogenesis evident by the inhibition of CD31 staining in tumor sections. EOC317 is combinable with 5-FU or paclitaxel without diminishing the activity or increasing the toxicity of these chemotherapy agents in the HCT-116 colon tumor xenograft model

参考文献：

1. Patel K, et al. ACTB-1003: An oral kinase inhibitor targeting cancer mutations (FGFR), angiogenesis (VEGFR2, TEK), and induction of apoptosis (RSK and p70S6K). Journal of Clinical Oncology 28, no. 15 DOI: 10.1200/jco.2010.28.15_suppl.e13665

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.691 ml	8.453 ml	16.905 ml
5 mM	0.338 ml	1.691 ml	3.381 ml
10 mM	0.169 ml	0.845 ml	1.691 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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