货号	规格	价格	上海	北京	珠海	重庆	武汉
S87489-1mg买3赠1	≥98%	￥580.00 S87489-1mg ￥580.00 现货（买3赠1）	10 10	-	-	-	-
S87489-5mg	≥98%	￥1370.00 S87489-5mg ￥1370.00 现货	10 0 10	-	-	-	-
S87489-10mg	≥98%	￥2670.00 S87489-10mg ￥2670.00 现货	9 9	-	-	-	-
S87489-25mg	≥98%	￥4420.00 S87489-25mg ￥4420.00 现货	4 4	-	-	-	-

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产品描述：

LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

靶点：

Tryptophan Hydroxylase;Hydroxylase; LPAReceptor

体内研究：

With oral administration of LX-1031 in mice, the average 5-HT reductions in the jejunum relative to control are appr 33, 51, and 66% with the 15, 45 and 135 mg/kg/day doses respectively. In a preliminary report, the effects of LX-1031, 100 mg/kg daily, on 5-HT levels in jejunal mucosa are reversible within 2 days of discontinuation in mice. LX-1031 dose-dependently reduces expression of 5-HT in the duodenum, jejunum and ileum, but has no effect on brain 5-HT levels in preclinical assay

参考文献：

1. Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200. 2. Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.857 ml	9.285 ml	18.569 ml
5 mM	0.371 ml	1.857 ml	3.714 ml
10 mM	0.186 ml	0.928 ml	1.857 ml
50 mM	0.037 ml	0.186 ml	0.371 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

LX-1031,TPH1抑制剂

LX-1031

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)