货号	规格	价格	上海	北京	珠海	重庆	武汉
S87490-5mg促销	99.60%	￥100.00 ￥80.00 S87490-5mg ￥80.00 现货	9 9	-	-	-	-
S87490-10mg促销	99.60%	￥150.00 ￥120.00 S87490-10mg ￥120.00 现货	10 10	-	-	-	-
S87490-50mg促销	99.60%	￥610.00 ￥488.00 S87490-50mg ￥488.00 现货	6 6	-	-	-	-
S87490-100mg促销	≥98%	￥1050.00 ￥945.00 S87490-100mg ￥945.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells

靶点：

IC50: 2.3 μM (hTRPV4), 5.9 μM (mTRPV4), 3.2 μM (rTRPV4);TRP/TRPVChannel

体内研究：

RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse. Animal Model: CPZ-induced demyelination mouse model (C57BL/6 male mice) Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl) Administration: Microinjector pump for 5 weeks Result: Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.

参考文献：

1. Kato K, et al. Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: a study to elucidate the action points of acidosis and search for putative target molecules. Eur J Pharmacol. 2011 Aug 1;663(1- 2. Liu M, et al. TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2018 Nov 5;12:392. 3. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.833 ml	14.164 ml	28.329 ml
5 mM	0.567 ml	2.833 ml	5.666 ml
10 mM	0.283 ml	1.416 ml	2.833 ml
50 mM	0.057 ml	0.283 ml	0.567 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

RN-1734

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)