| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87498-2mg买3赠1 |
99.30% | ￥210.00 |
9 | - | - | - | - |
|
S87498-5mg买3赠1 |
99.30% | ￥370.00 |
9 | - | - | - | - |
|
S87498-10mg买3赠1 |
99.30% | ￥510.00 |
8 | - | - | - | - |
|
S87498-50mg买3赠1 |
99.30% | ￥2060.00 |
7 | - | - | - | - |
|
S87498-100mg买3赠1 |
≥98% | ￥2880.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 4 nM (TASK1/KCNK3), 390 nM (TASK3/KCNK9);PotassiumChannel | ||||||||||||||||||||
| 体外研究： | ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM | ||||||||||||||||||||
| 参考文献： | 1. Zou B, et al. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. Probe Reports from the NIH Molecular Libraries Program [Internet]. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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