货号	规格	价格	上海	北京	珠海	重庆	武汉
S87518-5mg买3赠1	≥98%	￥590.00 S87518-5mg ￥590.00 现货（买3赠1）	6 6	-	-	-	-
S87518-10mg买3赠1	≥98%	￥952.00 S87518-10mg ￥952.00 现货（买3赠1）	7 7	-	-	-	-
S87518-25mg	98.40%	￥1660.00 S87518-25mg ￥1660.00 现货	1 1	-	-	-	-
S87518-100mg	≥98%	￥4630.00 S87518-100mg ￥4630.00 现货	2 2	-	-	-	-

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产品描述：

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

靶点：

Bacterial;ribosome; Antibacterial

体外研究：

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.

参考文献：

1. Goralski TD, et al. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.746 ml	13.728 ml	27.456 ml
5 mM	0.549 ml	2.746 ml	5.491 ml
10 mM	0.275 ml	1.373 ml	2.746 ml
50 mM	0.055 ml	0.275 ml	0.549 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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