| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87537-1mg买3赠1 |
99.07% | ￥199.00 |
9 | - | - | - | - |
|
S87537-5mg买3赠1 |
99.07% | ￥590.00 |
6 | - | - | - | - |
|
S87537-10mg促销 |
99.07% | ￥800.00 ￥640.00 |
9 | - | - | - | - |
|
S87537-25mg促销 |
99.07% | ￥1690.00 ￥1350.00 |
3 | - | - | - | - |
|
S87537-100mg促销 |
≥99% | ￥4690.00 ￥3750.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Mavatrep is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain | ||||||||||||||||||||
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| 靶点： | TRP/TRPV Channel;TRP/TRPVChannel | ||||||||||||||||||||
| 体外研究： | In cells expressing recombinant human TRPV1 channels, Mavatrep antagonized capsaicin-induced Ca2+ influx with an IC50 of 4.6 nM. Mavatrep blocked the activation of hTRPV1 channels by Capsaicin (1 μM, pH 5.0) in a concentration-dependent fashion | ||||||||||||||||||||
| 体内研究： | In the complete Freund's adjuvant- and carrageenan-induced thermal hypersensitivity models, Mavatrep exhibited full efficacy, with ED80 values of 7.8 and 0.5 mg/kg, respectively, corresponding to plasma levels of 270.8 and 9.2 ng/mL, respectively. On the basis of Mavatrep superior pharmacologic and safety profile, Mavatrep was selected for clinical development for the treatment of pain | ||||||||||||||||||||
| 参考文献： | 1. Parsons WH, et al. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). J Med Chem. 2015 May | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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