货号	规格	价格	上海	北京	珠海	重庆	武汉
S87574-5mg促销	99.80%	￥400.00 ￥280.00 S87574-5mg ￥280.00 现货	6 6	-	-	-	-
S87574-10mg促销	99.80%	￥600.00 ￥420.00 S87574-10mg ￥420.00 现货	4 4	-	-	-	-
S87574-25mg促销	99.80%	￥1000.00 ￥510.00 S87574-25mg ￥510.00 现货	6 6	-	-	-	-
S87574-100mg促销	99.80%	￥1800.00 ￥1100.00 S87574-100mg ￥1100.00 现货	7 7	-	-	-	-

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产品描述：

Brequinar (DUP785, NSC 368390)是二氢乳清酸脱氢酶DHODH抑制剂，在体外IC50约为20 nM

靶点：

DHODH:20 nM;VirusProtease; Dehydrogenase; DNA/RNASynthesis

体内研究：

Brequinar sodium (BQR) induces anemia through inhibition of DHO-DHase activity and de novo pyrimidine synthesis in vivo. Coadministration of BQR with uridine prevents anemia

细胞实验：

Cell lines: splenic T cells isolated from BALB/c mice Concentrations: 0.26, 1.3, 2.6 μM Incubation Time: 40-66 h Method: Lymphocytes are isolated from BALB/c spleen by centrifugation through a Ficol gradient and are depleted of macrophages and B cells by adherence to goat anti-mouse IgG-coated plates. The nonadherent cells are harvested and cultured at 4 to 5× 105/ml in RPMI 1640 supplemented with 10% FBS. Stimulation is performed with 5 μg/ml Con A in the presence of indicated concentrations of Brequinar or uridine. After 40 to 66 h, the cells are harvested and the levels of cell proliferation or purine NTP and PyNTP are quantified.

参考文献：

1. Sykes DB, et al. Cell. 2016, 167(1):171-186.e15. 2. Xu X, et al. J Immunol. 1998 Jan 15;160(2):846-53.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.664 ml	13.32 ml	26.64 ml
5 mM	0.533 ml	2.664 ml	5.328 ml
10 mM	0.266 ml	1.332 ml	2.664 ml
50 mM	0.053 ml	0.266 ml	0.533 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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