| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87576-1mg促销 |
98% | ￥130.00 ￥116.00 |
10 | - | - | - | - |
|
S87576-5mg促销 |
98% | ￥400.00 ￥360.00 |
10 | - | - | - | - |
|
S87576-10mg促销 |
98% | ￥700.00 ￥630.00 |
8 | - | - | - | - |
|
S87576-25mg促销 |
98% | ￥1280.00 ￥1150.00 |
6 | - | - | - | - |
|
S87576-50mg促销 |
98% | ￥2300.00 ￥2070.00 |
3 | - | - | - | - |
|
S87576-100mg促销 |
98% | ￥3600.00 ￥3240.00 |
2 | - | - | - | - |
|
| 产品描述： | PD 117519 (CI947) is an A2A adenosine agonist which has shown oral antihypertensive activity in pharmacological animal models | ||||||||||||||||||||
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| 靶点： | A2A adenosine;AdenosineReceptor | ||||||||||||||||||||
| 体内研究： | PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing.Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing. Animal Model: 24 male beagle dogs (8-12 months old) Dosage: 2 mg/kg or 10 mg/kg Administration: Oral administration; 16 hours and 24 hours Result: Increased in mean heart rate and decreased in mean indirectsystolic blood pressure at time of highest drug exposure. Induced acute coronary arteriopathy. The endothelium also appears injured. | ||||||||||||||||||||
| 参考文献： | 1. Reynolds DL, et al. Liquid chromatographic analysis of the adenosine agonist PD 117519 in dog plasma. J Pharm Biomed Anal. 1991;9(4):345-9. 2. Tobin GA, et al. The role of eNOS phosphorylation in causing drug-induced vascular injury. Toxicol Pathol. 2014 Jun;42(4):709-24. 3. Enerson BE, et al. Acute drug-induced vascular injury in beagle dogs: pathology and correlating genomic expression. Toxicol Pathol. 2006;34(1):27-32. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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