| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87581-25mg促销 |
99.14% | ￥224.00 ￥140.00 |
6 | - | - | - | - |
|
S87581-100mg促销 |
99.14% | ￥360.00 ￥290.00 |
5 | - | - | - | - |
|
S87581-500mg |
≥98% | ￥640.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide. | ||||||||||||||||||||
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| 靶点： | NADPH;Potassium Channel;PotassiumChannel; NADPH | ||||||||||||||||||||
| 体内研究： | Acetohexamide (Compound AH) (100 mg/kg 悬浮于水中，口服，单剂量) 与苯丁诺酮 (PBZ) 联合使用可增强兔模型中的降血糖作用。 | ||||||||||||||||||||
| 参考文献： | 1. Gopalakrishnan M, et al. Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells. Br J Pharmacol. 2000 Apr;129(7):1323-32. 2. Imamura Y, et al. Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide. Life Sci. 2001 Sep 7;69(16):1947-55. 3. Aldawsari H, et al. Int J Pharm. 2013 Sep 10;453(2):315-21. 4. McMahon RE, et al. The nature of the metabolites of acetohexamide in the rat and in the human. J Pharmacol Exp Ther. 1965 Aug;149(2):272-9. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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