货号	规格	价格	上海	北京	珠海	重庆	武汉
S87624-5mg买3赠1	99.70%	￥400.00 S87624-5mg ￥400.00 现货（买3赠1）	8 8	-	-	-	-
S87624-10mg买3赠1	99.70%	￥600.00 S87624-10mg ￥600.00 现货（买3赠1）	5 5	-	-	-	-
S87624-25mg促销	99.70%	￥1120.00 ￥896.00 S87624-25mg ￥896.00 现货	3 3	-	-	-	-
S87624-100mg促销	≥98%	￥2880.00 ￥2300.00 S87624-100mg ￥2300.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist.

体外研究：

DIM-C-pPhCO2Me inhibited growth and induced apoptosis in ACHN and 786-O cells. DIM-C-pPhCO2Me decreased NR4A1-dependent transactivation in RMS cells and inhibited RMS cell and tumor growth and induced apoptosis. Both NR4A1 knockdown and treatment with DIM-C-pPhCO2Me also induced ROS which activated stress genes and induced sestrin 2 which activated AMPK and inhibited mTOR in the mutant p53 RMS cells

体内研究：

Knockdown of NR4A1 in ACHN and 786-O cells was carried out using Lipofectamine 2000 reagent according to the manufacturer's protocol. siRNA complexes used in the study are as follows: siGL2-5', CGU ACG CGG AAU ACU UCG A; siNR4A1 (1)-SASI_Hs02_00333289; siNR4A1 (2)-SASI_Hs01_00182072. ACHN RCC cells were plated on 12-well plates at 5 x 104 cells per well in DMEM supplemented with 2.5% charcoal-stripped FBS. After 24 hr, various amounts of DNA [NBRE3-luc (400 ng), FLAG-NR4A1 (40 ng)] were cotransfected into each well by Lipofectamine 2000 reagent according to the manufacturer's protocol. After 6 hr of transfection, cells were treated with 2.5% stripped DMEM containing either DMSO, DIM-C-pPhOH (20 μM) or DIM-C-pPhCO2Me (15 μM) for 18 hr

参考文献：

1. Lacey A, et al. Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget. 2016 May 24;7(21):31257-69. 2. Hedrick E, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One. 2015 Jun 2;10(6):e20128308.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.629 ml	13.143 ml	26.285 ml
5 mM	0.526 ml	2.629 ml	5.257 ml
10 mM	0.263 ml	1.314 ml	2.629 ml
50 mM	0.053 ml	0.263 ml	0.526 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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