货号	规格	价格	上海	北京	珠海	重庆	武汉
S87638-5mg买3赠1	98.10%	￥238.00 S87638-5mg ￥238.00 现货（买3赠1）	4 4	-	-	-	-
S87638-10mg买3赠1	98.10%	￥408.00 S87638-10mg ￥408.00 现货（买3赠1）	8 8	-	-	-	-
S87638-25mg买3赠1	98.10%	￥652.00 S87638-25mg ￥652.00 现货（买3赠1）	5 5	-	-	-	-
S87638-100mg买3赠1	≥98%	￥2170.00 S87638-100mg ￥2170.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC50s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2. Tyrphostin AG 528 is also an anticancer agent

靶点：

EGFR:4.9 μM (IC50);ErbB2:2.1 μM (IC50);EGFR

体外研究：

In the present study, the interaction between drug Tyrphostin AG528 and CNT(6,6-6) nanotube by Density Functional Theory (DFT) calculations in solvent water has been investigated for the first time. According to the calculations, intermolecular hydrogen bonds take place between an active position of the molecule Tyrphostin AG528 and hydrogen atoms of the nanotube which play an important role in the stability of complex CNT(6,6- 6)/Tyrphostin AG528. The non-bonded interaction effects of the molecule Tyrphostin AG528 with CNT(6,6-6) nanotube on the electronic properties, chemical shift tensors and natural charge have also been detected. The natural bond orbital (NBO) analysis suggested that the molecule Tyrphostin AG528 as an electron donor and the CNT(6,6-6) nanotube play the role of an electron acceptor at the complex CNT(6,6-6)/Tyrphostin AG528

参考文献：

1. Naijue Zhu, et al. Tyrphostin Tumor Growth Inhibitors of EGFR and ErbB2 Tyrosine Kinase. J Chem Crystallogr. 2007, 37, 679–683. 2. Sheikhi M, et al. Investigation of Adsorption Tyrphostin AG528 Anticancer Drug Upon the CNT(6,6-6) Nanotube: A DFT Study. Curr Mol Med. 2019;19(2):91-104.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.265 ml	16.323 ml	32.646 ml
5 mM	0.653 ml	3.265 ml	6.529 ml
10 mM	0.326 ml	1.632 ml	3.265 ml
50 mM	0.065 ml	0.326 ml	0.653 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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